Overview
| Scheme |  |
| Description | Given the rapid depletion of fossil fuels and the resulting climate change, this research thematic aims to develop new water oxidation catalysts (WOCs) for the production of "solar fuels". In this project, our investigations deal with the correlation between the performance and stability of the catalyst related to its geometric and electronic structure. In this context, this project aims to develop robust WOCs based on the recent successes of Ruthenium-based WOC. The ligand design will be finely adjusted to optimize its catalytic efficiency and its turnover. A variety of functionalized ligands containing a combination of azaheterocycles substituted by anionic functional groups is used to improve the coordination sphere of the ligand for the Ruthenium metal. |
| Collaboration(s) | Institut of Chemical Investigations of Catalonia (ICIQ, Espagne) |
| Financial support | None |
| Sign. Publications (2 max.) | ACS CATALYSIS, 2018, 8 (3), 2039-2048, doi,
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (11), 5068-5077, doi, |
| Personnels impliqués | D. Dubreuil ; J. Lebreton ; M. Pipelier ; A. Tessier |
| Scheme | |
| Description | Since 2018, our team has been collaborating with the group led by Professor Saïd El Kazzouli at Euromed Center in Fes (Morocco). Our commun interest lies in the development of new synthetic methodologies in heterocyclic chemistry, and specifically in indazole chemistry, due to the potential biological properties of these compounds.
New methods for the regioselective arylation of various positions on this heterocycle have been developed (RSC Adv., 2021, Synthesis 2022 Asian J. Org. Chem, 2023). We recently expanded our expertise to macrocyclic systems incorporating the indazole moiety, studying cyclic metathesis reaction with a series of diene precursors. |
| Collaboration(s) | Euromed Centre de Recherche, Université Euro-Méditerranéenne de Fès (Maroc) |
| Financial support | Marocco PhD student internships |
| Sign. Publications (2 max.) | (1) RSC Adv., 2021, 11, 7107-7114, DOI: 10.1039/d0ra08598g.
(2) Synthesis 2022, 54(21), 4834-4842, DOI: 10.1055/a-1891-0797. (3) Asian J. Org. Chem. 2023, 12, e202300285. doi.org/10.1002/ajoc.202300285. |
| Personnels impliqués | L. Arzel, S. Collet, J. Lebreton, M. Mathé-Allainmat, M. Pipelier, |
| Scheme |  |
| Description
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The quest for new scaffolds possessing biological activities represents a challenge for pharmaceutical industry. The discovery of "leads" is a necessary and time-consuming process in the development of new drugs for medicinal applications. Therefore, the development of new methodologies allowing a rapid access to original skeletons from simple precursors is a topic of high interest, both on its fundamental aspect and for the synthetic applications that might arise from this work. We have developed an original and robust access to -lactols, methylene--lactols, and -butenolides based upon the unprecedented radical cyclisation of -haloaluminium acetals. We also develop original strategies based upon remote C–H bond functionalization to prepare versatile polysubstituted vinyl-cyclopentane derivatives, which are useful building block for the elaboration of more complex targets of interest for the group. |
| Collaboration(s) | IRCOF Rouen ; Universitãt Bern (Suisse); Trinity College Dublin (Irlande); Melbourne University (Australie); Universidad de Valladolid (Espagne) |
| Financial support | ANR JCJC Radic[Al] (2010-2014; 160 K€)) and ANR Blanc UZFUL-Chem (2013-18; 240 K€)
Programmes européens COST (CM1201 « Biomimetic Radical Chemistry » et CA15106 CHAOS « C--H Activation in Organic Synthesis ») IEA (ex-PICS) CNRS «CasChem» 2018-2020 (15 K€) |
| Sign. Publications (2 max.) | PURE AND APPLIED CHEMISTRY, 2016, 88 (3), 215-225, doi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2017, 56 (43), 13329-13332, doi |
| Personnels impliqués | F. Dénès; J. Lebreton ; L. Arzel |