The AMaCC platform is involved in various research projects focused on the following areas: fine and medicinal chemistry, the environment, and energy.
Glutarldehyde
Objective:
Quantification of residual impurities in rinsing solutions for medical devices.
Partners:
Inserm UMRS1229 RMeS (University Hospital of Nantes)
AMaCC’s involvement:
Development of an UPLC-UV-Vis method for quantifying impurities and development of a sample preparation method.
Superferatite
Objective :
Superferrimagnetic nanoassemblies for dual treatment of autoimmune hepatitis.
Partners:
IMF team (CEISAM laboratory, Nantes)
AMaCC’s involvement:
Development of analytical methods and LCMS quantification of hydrophobic molecules derived from curcumin via α-diketone functionalization (Kno-Cₓ).
LCMS quantification of derivatives synthesized by nanoassembly.
LCMS kinetic monitoring of the biodegradation of these compounds.
A manuscript is currently being written.
PARADyes
Objective:
Synthesis of prodrugs and development of enzyme-triggered fluorescent probes.
Partners:
CEISAM Symbiose team (CEISAM laboratory, Nantes), IICIMED UR1155 (Nantes)
AMaCC’s involvement:
Development of LC-MS analytical methods for prodrugs. Kinetic monitoring of enzymatic release by LC-MS.
Coordination compounds
Objective:
Characterize various coordination complexes despite several challenges:
- Absence of NMR analyses due to the paramagnetic nature of the chemical species.
- Low solubility.
- Fragmentation and rearrangement processes leading to unexpected peaks.
- Redox reactions occurring in the ESI source, generating unexpected charge states.
Partners:
Symbiose and IMF research groups, CEISAM laboratory.
AMaCC’s involvement:
Identification of diagnostic peaks for coordination complexes in the absence of the molecular ion. This work was presented at the MassChem 2026 conference held in Nancy.
Kinetic monitoring of cycloaddition
Objective:
Identify an original reaction intermediate in a cycloaddition reaction.
Partners:
Corail research group, CEISAM laboratory.
AMaCC’s involvement:
Kinetic monitoring was performed by ESI direct infusion of the reaction medium, allowing the identification of several intermediates, notably by HRMS and MS/MS analyses.A manuscript is currently being prepared.
QUINOA
Objective:
Axially chiral quinolones: atroposelective synthesis and applications in catalysis.
Partners:
CORAIL team (CEISAM laboratory, Nantes)
AMaCC’s involvement:
Development of methods for the chiral separation of various racemic molecules and determination of the enantiomeric excesses of all synthesized molecules.
« ESPoiR » project
Objective:
Studying and understanding the possible links between enantiomerism and natural isotopic composition
Partners:
CNRS project, in collaboration with the MIMM team (CEISAM laboratory, Nantes)
AMaCC’s involvement:
Development of a chiral HPLC method for the separation of the R and S enantiomers of 1-phenylethan-1-ol then determination of the enantiomeric excess upstream of the NMR analysis.
« e-Y-Click » project
Objective:
Electrochemistry coupled to mass spectrometry for the prediction of environmental and in vivo degradation of pesticides
Partners:
A collaborative project with the Department of Chemistry at the University of Dschang in Cameroon, the Department of Fisheries and Wildlife at the University of Michigan in the United States, and the IMF team (CEISAM laboratory, Nantes)
AMaCC’s involvement:
- EC-MS coupling
- ULC-MS and ULC-MS² analysis
« BRANCH » project
Objective:
Development of Pickering-modified bitumen based on bio-based nanoparticles for improved cold-mix asphalt.
Partners:
I-Site NEXT “Industry of the Future” project in collaboration with the IMF team (CEISAM laboratory, Nantes), the IFSTTAR laboratory (Gustave Eiffel University, Nantes), and the BIA laboratory (INRAE, Nantes), EUROVIA Management Company
AMaCC’s involvement:
Development of a purification (clean-up) method for a complex matrix (asphalt fumes) to quantify 16 PAHs using HPLC-UV.
ANSES Research and Development Agreement: Bituminous Road Products
Objective:
Toward a new methodology for evaluating materials and their emissions.
Partners:
MAST-MIT team (Gustave Eiffel University, Bouguenais), CEREMA laboratory (Carnot Institute), the Roman University Institute of Occupational Health in Lausanne (Switzerland), ICPEES laboratory (University of Strasbourg)
AMaCC’s involvement:
Development of a method for the separation and quantification of 43 PAHs using HPLC-UV and GCMS. Participation in interlaboratory cross-validation tests (Round Robin test).
« Bitume 2.0 » project
Objective:
Development and characterization of an alternative binder to petroleum bitumen, produced from renewable biomasses
Partners:
A collaborative project with ADEME, the TOTEM team (CEISAM laboratory, Nantes), the RTO laboratory at CEA-Liten (Carnot Institute), the ITERG industrial technology center, and the IFSTTAR laboratory (Gustave Eiffel University, Bouguenais)
AMaCC’s involvement:
Characterization of pure compounds and complex mixture.
« Intra Tree » project
Objective:
Development of intramolecular 13C as a tool for monitoring trees’ response to climate change.
Partners:
MIMM Team (CEISAM, Nantes), LSCE Laboratory (UMR 8212, Gif-sur-Yvette), IRHS Laboratory (UMR 1345), IANIGLA (Argentina)
AMaCC’s involvement:
Development of the UPLC DEDL separation method using a HILIC column and quantification of glucose obtained after hydrolysis of cellobiose (itself derived from cellulose) and the glucose derivatives MAGF and DAGF.