The AMaCC platform is currently involved in several different research projects around four subjects: Kinetic study of reactions in synthetic chemistry, Study of bituminous compounds, Couplings in Mass Spectrometry and Measurement of enantiomeric excesses.
Superferatite
Project's goal:
Development of hybrid nano-assemblies - an organic matrix (derived from curcumin) encapsulating inorganic nanoparticles (iron oxide nanoparticles) functionalized by a peptide - for the treatment of autoimmune hepatitis.
Project leader / Fundings:
Dr. Lenaic LARTIGUE, MC, CEISAM, Nantes / 2019-2022, Region Pays de La Loire funding (€ 151 k)
AMaCC involvement:
- Quantitation of curcumin derivatives synthesized by nano-assembly (LC/MS)
- Monitoring of their biodegradation (LC/MS)
PARADyes
Project's goal:
Réalisation de prodrogues et élaboration de sondes fluorescentes à déclenchement enzymatique.
Project leader / Fundings:
Dr. Arnaud TESSIER, CR, CEISAM, Nantes / 2016-2021, Region Pays de La Loire funding (€ 200 k)
AMaCC involvement:
- Kinetic monitoring of enzymatic triggering (LC/MS)
Intratree
Project's goal:
Development of 13C intramolecular as a tool for monitoring the response of trees to climate change.
Project leader / Fundings:
Pr. Valérie DAUX, LSCE, Gif sur Yvette / 2016-2021
AMaCC involvement:
- Kinetic monitoring of the hydrolysis of cellobiose into glucose
- Monitoring of glucose derivatization into MAGF and DAGF
Bituminous products
Project's goal:
Study of a new methodology for the evaluation of materials and their emissions.
Project leader / Fundings:
Dr. Vincent GAUDEFROY, IFSTTAR, Nantes / 2014-2018, ANSES fundings (€ 115 k)
AMaCC involvement:
- Dosage of 43 PAHs (Polycyclic Aromatic Hydrocarbons) potentially present in asphalt mix emissions.
Bitume 2.0
Project's goal:
Development and characterization of an alternative binder to petroleum bitumen, produced from renewable biomasses
Project leader / Fundings:
DURAND J. Lalo – COLAS company / 2019-2022, financement ADEME fundings (€ 400k)
AMaCC involvement:
- Characterization of pure compounds and complex mixture.
Projet BRANCH
Project's goal:
Pickering bitumen stabilized by biobased nanoparticles for improved cold mix asphalt
Project leader / Fundings:
Dr. Bruno BUJOLI, DR, CEISAM / 2015-2019, I-Site NEXT fundings (€ 238 k)
AMaCC involvement:
- Sample preparation : Complex Clean-up (successive extractions and purifications on normal phase and C18 columns)
- Determination of the 16 PAHs of the US-EPA
« Electrochemistry coupled to Mass Spectrometry »
Project's goal:
Electrochemistry coupled to mass spectrometry for the prediction of environmental and in vivo degradation of pesticides
Project leader / Fundings:
Dr. Mohammed BOUJITA, MC, CEISAM, Nantes / 2016-2020, France Ambassy in Cameroun fundings (€ 16 k) and CEISAM IMF team (€ 25 k)
AMaCC involvement:
- Couplage EC-MS
- Analyses ULC-MS et ULC-MS²
Scentific production
- Temgoua R. et al, Electrochimica Acta, Volume 352, 2020, 136485. doi
- Temgoua R. et al, Talanta, Volume 221, 2021, 121448. doi
« ESPoiR » project
Project's goal:
Studying and understanding the possible links between enantiomerism and natural isotopic composition
Project leader / Fundings:
Pr Gérald REMAUD, CEISAM / 2018,2019, CNRS fundings (€ 20k)
AMaCC involvement:
- Development of a chiral HPLC method for the separation of the R and S enantiomers of 1-phenylethan-1-ol then determination of the enantiomeric excess upstream of the NMR analysis.