MIMM team

Overview

Team leader: Patrick GIRAUDEAU

The MIMM team (Magnetic resonance, isotopomics, metabolomics, monitoring) is composed of around 25 persons with complementary expertise in analytical and physical chemistry, particularly in the fields of solution-state nuclear magnetic resonance (NMR) spectroscopy and isotope analysis at natural abundance, and their application to a broad variety of fields such as metabolism, authentication, forensics or reaction monitoring.

Publications since 2021 are available at this link.

Research subjects

With numerous major grants in the recent years (several international programs including three ERC and many ANR and regional grants), the MIMM team has become an international leading research group in two major domains:

  1. Fast and accurate NMR spectroscopy of complex mixtures, featuring groundbreaking advancements in quantitative NMR, in fast multipulse NMR and hyperpolarized NMR, as well as highly innovative applications in metabolomics and reaction monitoring.
  2. Isotopomics, consisting in the accurate measurement of position-specific isotope natural abundance variations, by high precision quantitative NMR and isotope ratio mass spectrometry, with original applications to fields such as metabolism, environment, authentication or forensics.

The MIMM team is constantly expanding its expertise, particularly in the development of 2D NMR methods based on spatial encoding. These methods are applied to the monitoring of reactions and processes, whether at high or medium field. They are also combined with dissolution dynamic nuclear polarization to enhance NMR sensitivity.

A large part of our developments and applications are devoted to metabolomics, as part of our strong commitment in the Corsaire metabolomics core facility and in the MetaboHUB national infrastructure. This metabolomics expertise is also combined with isotopomics, through the development of innovative "all-in-one" methods. The team applications are also available to external customers (industry and academic) through Nantes Université subsidiary, Capacités.