CAROS - Design of Singlet Oxygen Reservoir Photosensitizers for Antibacterial Applications
CAROS is a project led by Vincent COEFFARD is to develop novel photosensitizers able to generate, store and selectively release singlet oxygen for applications in antibacterial photodynamic therapy (PTDA).
Project summary
Singlet oxygen is an excited state of oxygen with applications in organic synthesis, materials and photomedicine, in particular, antibacterial photodynamic therapy (ATDP). Photosensitizers capable of generating, storing and selectively releasing singlet oxygen are sought-after compounds for PDTA, whose efficacy is highly dependent on oxygen concentration. This is the background to the CaROS project, which aims to develop an original synthesis methodology for a new family of photosensitizers with singlet oxygen reservoirs. In addition to the synthetic aspect, photophysical studies and antibacterial tests have been carried out to assess the therapeutic potential of the prepared molecules. Based on preliminary work, results have been obtained both in organic synthesis and in the development of new antibacterial agents.