The development of new methods for early diagnosis, prognosis and therapeutic strategies relies heavily on the discovery of biomarkers.
INDEED-IRMS builds on our first patented results and develops new detection methods in Isotope Ratio Mass Spectrometry (IRMS), 15N position-specific isotope analysis on-line (15N-PSIA). The natural abundance of nitrogen 15 at different nitrogen atom positions will be measured within intermediates of the urea cycle modified in cancer.
The potential of our new approach will be demonstrated by applying it to breast cancer serum and tissue samples from different subtypes expressing different hormone receptors to better understand their metabolism. Using theoretical models to understand variations in 15N, 15N-PSIA analysis by IRMS will investigate how nitrogenous metabolic fluxes are pathophysiologically altered.
This project brings together a consortium of internationally renowned isotope experts and a world-renowned IRMS company to help build a system suitable for routine PSIA analysis of innovative biomarkers in cancer and a variety of other fields.
