On Friday, November 22, 2024 at 11h, Prof. Rapahaël TRIPIER will give a seminar at CEISAM entitled “Harnessing Cationic Metal Coordination and Polyazacycloalkane Synthesis for Diagnostic and Therapeutic Applications”.
Harnessing Cationic Metal Coordination and Polyazacycloalkane Synthesis for Diagnostic and Therapeutic Applications
The importance of azamacrocycles in diagnosis (MRI, SPECT, PET, optical probes) and therapy (radiotherapy, photodynamic therapy) is now well established. They are indeed recognized to form highly stable and inert chelates that allow for safe in vivo application eg: the famous DOTA chelator is now a clear standard used as a complexing unit in several clinical cases: DOTAREM (Gd-MRI agent), 68Ga-DOTATE (PET-imaging), LUTATHERA (177Lu-radiotherapy).
However, the current challenge to find good chelators, able to be used in both diagnostic and therapeutic applications, persists since there is still no “ideal” ligand capable of coordinating a range of metallic cations of interest and that provides, only by changing the cationic core, imaging and therapeutic functions.
Our new, specially designed azaligands that are able to take on this challenge will be presented from their synthesis to their in vitro or in vivo application after metal complexation.
Keywords: Organic synthesis. Coordination chemistry. Transition metals. Lanthanides. Optical imaging. MRI. PDT. Nuclear medicine.